Microenvironment-derived factors driving metastatic plasticity in melanoma
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چکیده
منابع مشابه
Microenvironment-derived factors driving metastatic plasticity in melanoma
Cellular plasticity is a state in which cancer cells exist along a reversible phenotypic spectrum, and underlies key traits such as drug resistance and metastasis. Melanoma plasticity is linked to phenotype switching, where the microenvironment induces switches between invasive/MITFLO versus proliferative/MITFHI states. Since MITF also induces pigmentation, we hypothesize that macrometastatic s...
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1 Institute of Cell Biology, Histology and Embryology, Medical University Graz, Graz, Austria, 2 Institute for Medical Research, University of Belgrade, Belgrade, Serbia, 3 AO Research Institute, Davos, Switzerland, 4 IZKF Group Tissue Regeneration in Musculoskeletal Diseases, Orthopedic Center for Musculoskeletal Research, University of Würzburg, Würzburg, Germany, 5 Belgrade Metropolitan Univ...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2017
ISSN: 2041-1723
DOI: 10.1038/ncomms14343